pathogenesis of alzheimer disease pdf

Experimental evidence suggests that excitotoxicity participates in the pathogenesis of many neurodegenerative disorders of the central nervous system.
Authors: Hampel, Harald, article Type: Review Article, abstract: Amyloid- (A) deposition in the brain is one of the key pathological features of Alzheimer's disease (AD).
As the disorder progresses, some people with Alzheimer disease experience personality and behavioral changes and have trouble interacting in a socially appropriate manner.Forgetfulness may be subtle at first, but the loss of memory worsens over time until it interferes with most aspects of daily living.Klin Farmakol Farm 2004: 18(2 81-89.The early-onset form is much less common than the late-onset form, accounting for less than 5 percent of all cases of Alzheimer disease.These pathophysiological processes and mechanisms may dynamically and non-linearly evolve through fully reversible adaptive compensatory stages and through reactive decompensatory stages into fully irreversible neurodegenerative stages.Death usually results from pneumonia, malnutrition, or general body wasting (inanition).N-methyl-D-aspartate (nmda) receptors belong to the group of ionotropic glutamate receptors and together with ampa/kainate receptors mediate fast excitatory synaptic transmission in the brain and spinal cord and play a key role in maintaining complex functions of the central nervous system.Affected people increasingly require help with dressing, eating, and personal care.Even in familiar settings, a person with Alzheimer disease may get lost or become confused.Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function.



N-metyl-D-aspartátové (nmda) receptory patí do skupiny ionotropních glutamátovch receptor, které spolen s dalím podtypem glutamátovch receptor - ampa/kainátovm receptorem zprostedkovávají rychl synaptick penos na vtin excitaních synapsí v centrální nervové soustav.
Existují experimentální dkazy o tom, e se excitotoxicita podílí na vzniku celé ady neurodegenerativních onemocnní a e antagonisté nmda receptor mohou pedstavovat terapeutick potenciál pro lébu onemocnní vykazující jak akutní, tak chronické formy neurodegenerace vetn Alzheimerovy demence.
Keywords: nmda receptor, excitotoxicity, glutamate, memantin, Alzheimer dementia, ion channel blocker.
People with this disease usually require total care during avast pro antivirus with key the advanced stages of the disease.Fyziologick ústav AVR, Praha, klíová slova: nmda receptory, excitotoxicita, glutamát, memantin, Alzheimerova demence, bokátor iontového kanálu.Excessive activation of nmda receptors results in pathological states that may lead to a specific form of neuronal cell death (excitotoxicity).Keywords: Alzheimer's disease, amyloid-, amyloid cascade hypothesis, asymptomatic, biomarkers, connectivity, CSF, default mode network, dementia, detection, diagnosis, dimers, DMN, fMRI, mild cognitive impairment, molecular mechanisms, neurophysiology, network paradigm, neural networks, oligomers, pathophysiology, preclinical, prodromal.Alzheimer disease can be classified as early-onset or late-onset.